Preparation and standardisation of 0.05 M Barium Chloride solution using Disodium edetate and Metalphthalein as indicator used in pharmaceutical analysis.
Barium Chloride Solution Preparation
- Dissolve 12.2 g of barium chloride in sufficient water to produce 1000 ml.
- Standardize the solution in the following manner.
Barium Chloride Solution Standardization
- To 10.0 ml of the solution add 60 ml of water, 3 ml of strong ammonia solution and 0.5 to 1 mg of metalphthalein as an indicator.
- Titrate with 0.05 M disodium edetate.
- As the solution begins to decolorize, add 50 ml of ethanol (95 %) and titrate until the bluish violet color is discharged.
- 1 ml of 0.05 M disodium edetate is equivalent to 0.012215 g of BaCl2.2H20.
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Dr. Ankur Choudhary is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question
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