Preparation and Standardization of 0.25 M Ethanolic Sulphuric Acid : Pharmaceutical Guidelines

Preparation and Standardization of 0.25 M Ethanolic Sulphuric Acid

Preparation and standardisation of 0.25 M Ethanolic Sulphuric Acid using Methyl Red solution as indicator used in pharmaceutical analysis.

Ethanolic Sulphuric Acid Solution Preparation:

•  Add slowly, with stirring, 13.9 ml of sulphuric acid to 900 ml ethanol.
•  Make up the volume with ethanol to produce 1000 ml.
•  Allow the solution to cool down.
•  Standardize the solution before use.

Ethanolic Sulphuric Acid Solution Standardization:

•  Weigh accurately about 800 mg of anhydrous sodium carbonate, previously heated at about 270 °C for 1 hour.
•  Dissolve it in 100 ml of water and add 0.1 ml of methyl red solution.
•  Add the acid slowly from a burette, with constant stirring, until the solution becomes faintly pink. Heat the solution to boiling, cool and continue the titration. Heat again to boiling and titrate further as necessary until the faint pink colour is no longer affected by continued boiling.
•  1 ml of 1 M hydrochloric acid is equivalent to 0.05299 g of Na2CO3.

                      Na2COin gm
M = -----------------------------------------
         Volume of H2SOin ml  x 52.99

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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